The use of solid phase microextraction as sample preparation technique for determination of n-nitrosodimethylamine in water polluted by hydrazine-based rocket fuel

Keywords: N-nitrosodimethylamine, solid-phase microextraction, 1, 1-dimethylhydrazine, gas chromatography, mass spectrometry, water


A paper describes a method for determination of N-nitrosodimethylamine in water, polluted by spills of 1,1-dimethylhydrazine, based on solid phase microextraction coupled to gas chromatography/mass spectrometry. A method detection limit was determined to be 1 ug/kg, relative error was below 20%. A method is very sensitive and selective as well as quite simple, relatively cheap and fully automated.


1 Carlsen L., Kenessov B.N., Batyrbekova S.Ye. A QSAR/QSTR study on the human health impact by the rocket fuel 1,1-dimethylhydrazine and its transformation products // Environmental Toxicology and Pharmacology. – 2009. - Vol. 27. - P. 415-423.

2 Mitch W.A., Sharp J.A., Trussell R.R., Valentine R.L., Alvarez-Cohen L., Sedlak D.L. N-nitrosodimethylamine (NDMA) as a drinking water contaminant: A Review // Environmental Engineering Science. - 2003. – Vol. 20, N.5. - P.389-404.

3 «Создание системы физико-химической диагностики содержания компонентов ракетного топлива и продуктов их превращения в объектах окружающей среды. Изучение физико-химических основ поведения компонентов жидкого ракетного топлива в различных объектах окружающей среды с моделированием процессов их трансформации и распространения» по Государственной программе «Развитие космической деятельности в Республике Казахстан» на 2005-2007 годы: Отчет о НИР / ДГП ЦФХМА; рук. - Наурызбаев М.К. – Алматы, 2006. – 171 с. - № ГР 0105РК00166. – Инв. № 0206РК01079.

4 Lunn G., Sansone E.B. Oxidation of 1,1-dimethylhydrazine with air and hydrogen peroxide // Chemosphere. – 1994. – Vol. 29(7). - P.1577-1590.

5 US EPA Method 521. Determination of nitrosoamines in drinking water by solid phase extraction and capillary column gas chromatography with large volume injection and chemical ionization tandem mass spectrometry (MS/MS). Version 1.0. – Cincinnati, Ohio, USA, 2004. - 47 p.

6 Grebel J.E., Young C.C., Suffet I.H. Solid phase microextraction of N-nitrosamines // Journal of Chromatography A. – 2006. – Vol. 1117. – P.11-18.

7 Zhang Zh., Pawliszyn J. Headspace solid-phase microextraction // Analytical Chemistry. – 1993. – Vol.65(14). – P.1843-1852.


Cited by: 4

1. Kenessov B, Alimzhanova M, Sailaukhanuly Y, et al (2012) Transformation products of 1,1-dimethylhydrazine and their distribution in soils of fall places of rocket carriers in Central Kazakhstan. Science of the Total Environment 427-428: 78-85. CrossRef

2. Kosyakov DS, Ulyanovskii NV, Pokryshkin SA (2015) Rapid determination of 1,1-dimethylhydrazine transformation products in soil by accelerated solvent extraction coupled with gas chromatography–tandem mass spectrometry. Int J Environ Anal Chem 95:1321-1337. CrossRef

3. Kenessov BN, Batyrbekova SY (2012) Actual directions in study of ecological consequences of a highly toxic 1,1-dimethylhydrazine-based rocket fuel spills. Chemical Bulletin of Kazakh National University 2:124-131. CrossRef

4. Kenessov BN, Carlsen L (2014) Identification (quantitative determination and detection) and fate of transformation products of rocket fuel 1,1-dimethylhydrazine. In: Lambropoulou LA, Nollet ML (eds.) Transformation Products of Emerging Contaminants in the Environment: Analysis, Processes, Occurrence, Effects and Risks. CrossRef

How to Cite
Kenessov, B. (2009). The use of solid phase microextraction as sample preparation technique for determination of n-nitrosodimethylamine in water polluted by hydrazine-based rocket fuel. Chemical Bulletin of Kazakh National University, (2), 92-97.