Hydrogel dressings with local anesthetic action
The association of the local anesthetic lidocaine hydrochloride (LD) with polyvinylpyrrolidone (PVP) in aqueous solution was investigated. It was shown that titration of PVP aqueous solution with lidocaine accompanied by an increase of viscosity. This indicates the complexation between charged molecules of anesthetic and macromolecules of PVP. As a result of such non-ionic interaction the PVP macromolecules charges and has the properties of polyelectrolyte. The polymer matrix based on lidocaine hydrochloride and PVP was synthesized. Complexation of matrix components was studied by IR-spectroscopy.
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