Development of hydrogel ointments with antituberculosis activity
In this work hydrogel ointments based on biopolymer for use as a transdermal therapeutic drug delivery systems for antituberculosis drug substances were obtained and studied. Ointments based on polyvinylpyrrolidone (PVP) with drugs isoniazid and ethambutol were created. The transdermal characteristics of ointments based on PVP and drug were investigated using a cellulose membrane and pig skin. The experiment was carried out on the device Franz cell. Diffusion coefficient (D), the permeability (P) and the permeation rate (F) of the drug were determined.
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