Development of hydrogel ointments with antituberculosis activity

  • M. Buribayeva al-Farabi Kazakh National University
  • Galiya Irmuhametova al-Farabi Kazakh National University
  • Grigoriy Mun al-Farabi Kazakh National University
Keywords: transdermal therapeutic system, drug delivery, polyvinylpyrrolidone, isioniazid, ethambutol

Abstract

In this work hydrogel ointments based on biopolymer for use as a transdermal therapeutic drug delivery systems for antituberculosis drug substances were obtained and studied. Ointments based on polyvinylpyrrolidone (PVP) with drugs isoniazid and ethambutol were created. The transdermal characteristics of ointments based on PVP and drug were investigated using a cellulose membrane and pig skin. The experiment was carried out on the device Franz cell. Diffusion coefficient (D), the permeability (P) and the permeation rate (F) of the drug were determined.

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Published
2013-05-14
How to Cite
Buribayeva, M., Irmuhametova, G., & Mun, G. (2013). Development of hydrogel ointments with antituberculosis activity. Chemical Bulletin of Kazakh National University, (2), 70-74. https://doi.org/https://doi.org/10.15328/chemb_2013_270-74
Section
Organic and Polymers Chemistry