Development of hydrogel ointments with antituberculosis activity
In this work hydrogel ointments based on biopolymer for use as a transdermal therapeutic drug delivery systems for antituberculosis drug substances were obtained and studied. Ointments based on polyvinylpyrrolidone (PVP) with drugs isoniazid and ethambutol were created. The transdermal characteristics of ointments based on PVP and drug were investigated using a cellulose membrane and pig skin. The experiment was carried out on the device Franz cell. Diffusion coefficient (D), the permeability (P) and the permeation rate (F) of the drug were determined.
1. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev., 2004, no 3. Р. 115–24.
2. Wang Y, Thakur R, Fan Q, Michniak B. Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur J Pharm Biopharm., 2005, no 60. Р.179–91.
3. Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci., 2001, no 14. Р. 101–14.
4. Jasti BR, Abraham W, Ghosh TK. Transdermal and Topical drug delivery systems In : Ghosh TK, Jasti BR, editors. Theory and Practice of Contemporary Pharmaceutics. 1st ed. Florida: CRC Press; 2005. p. 423-53.
5. D.A.Harkevich. Pharmacology [Farmakologiya]. Textbook for high schools. 8 ed.. Moscow: GEOTAR Media, 2005. P.596-604.
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