Development of the technology for obtaining new hydrogel materials based on acrylic monomers

Nazerke Dauletbayevna Nurabay; M. Abutalip; Raikhan Kulymbetovna Rakhmetullayeva; Grigoriy Alekseevich Mun

doi:10.15328/cb959

Nazerke Dauletbayevna Nurabay al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0001-7354-9502
M. Abutalip al-Farabi Kazakh National University, Almaty, Kazakhstan
Raikhan Kulymbetovna Rakhmetullayeva al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0003-1002-2046
Grigoriy Alekseevich Mun al-Farabi Kazakh National University, Almaty, Kazakhstan

Keywords: 2-hydroxyethyl acrylate, N-isopropylacrylamide, acrylic acid, hydrogen bond, gentamicin, lincomycin, hydrophobic interaction

Abstract

Smart water-soluble polymers and hydrogels are capable to reversibly react to insignificant changes of the medium properties (pH, temperature, ionic strength, a presence of some substances, illumination, electric field). The reacting of a system is visible to the naked eye (the formation of a new phase in a homogeneous solution, or compression of the hydrogel). The properties of such polymers and hydrogels are considered. For the first time, the stimuli-responsive polymeric hydrogels based on N-isopropylacrylamide (NIPAAM), 2-hydroxyethyl acrylate (HEA) and acrylic acid (AA) have been synthesized by free initiation of radical copolymerization. The purpose of the research is to obtain stimuli-responsive cross-linked terpolymers based on N-isopropylacrylamide, 2-hydroxyethyl acrylate and acrylic acid and study their physicochemical properties. The physicochemical methods such as scanning electron microscopy, differential scanning calorimetry, infrared spectroscopy, gravimetry, cathetometric and thermogravimetric analyses were used in this study. To determine the thermal and pH – sensitivity of the modified copolymer, the effect of temperature on the NIPAAM-НEA-AA nets (in different pH media) was studied. They are characterized by a thermally induced collapse and a dependence on a medium pH. The interaction of copolymers with drugs such as lincomycin and gentamicin was studied for using the new copolymers as a drug carrier. To study the antibacterial properties and the transportation of physiologically active substances of hydrogel, the elimination of specially prepared bacteria by hydrogels with various medicinal ingredients were conducted.

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