The method of production and modification of highly disperse silica for pharmaceutical and cosmetic preparations
The change in the dispersity, morphology and state of amorphous silicon dioxide (silica) powder depending on the conditions of mechanochemical treatment (MCT) in the mill of dynamic action and ultrasonic treatment (UST) in different aqueous solution is considered. Production of silicon dioxide in a highly disperse state is of importance, when using it in cosmetic and pharmaceutical preparations. Nanosilicic compositions are effective for delivering medicines to the connective tissues of the skin structure. When dispersing powder as surfactant and modifying additives, we used monoatomic and triatomic alcohols as well as succinic and acetylsalicylic acids, which provide a high level of grinding, modification of the particle surface and stabilization of a highly active state of silicon dioxide. Electron-microscopic investigations on the morphology of particles showed their capsulation into dense modifying films under the conditions of MCT and UST. The use of acid modifiers in the process of MCT and UST of silicon dioxide powder resulted in formation of complex composition systems consisting of an inorganic nucleus and organic capsulating film. The state of the obtained modified powders was evaluated by the change of electrical resistance as one of the most sensitive indices of structural changes of the system being treated. The use of triatomic alcohol glycerine, when treating the powder, noticeably decreased its specific electrical resistance after UST, due to formation of hydroxylic groups on the surface of particles and accumulation of charged particles, which provide a high chemical activity of the systems. An important role of the capsulating polymer component on the surface of highly disperse particles of silicon dioxide for stabilization of a highly active state of the powder is shown.
1 Ayler A (1982) Chemistry of silica [Khimiya kremniya] ed. by Pryanishkova VP. World [Mir], Moscow, Russia. Part 1. 416 p. and P.2. 712 p. (In Russian)
2 Villamo H (1990) Cosmetic Chemistry [Kosmeticheskaya khimiya]. World [Mir], Moscow, Russia. 285 p. (In Russian). ISBN 5-03-001352-0
3 Chuiko AA (2003) Medicinal chemistry and clinical application silica [Meditsinskaya khimiya i klinicheskoye primeneniye dioksida kremniya]. Naukova Dumka, Kiev, Ukraine. 417 p. (In Russian). ISBN 966-00-0185-1
4 Verbilovsky JP, Gerashchenko II, Yushchenko TI, Shtatko EI (1984) Pharmaceutical Chemistry Journal 2:45-50. (In Russian)
5 Abramov OV, Horbenko IG, Shvegla Sh (1984) Ultrasonic treatment materials [Ul’trazvukovaya obrabotka materialov]. Mechanical engineering [Mashinostroenie], Moscow, Russia. 280 p. (In Russian)
6 Khasanov OL, Dvilis ES, Polisadova VV, Zykov AP (2008) The effects of powerful ultrasonic action on the structure and properties of nanomaterials [Effekty moshchnogo ul’trazvukovogo vozdeystviya na strukturu i svoystva nanomaterialov]. Publishing House of Tomsk Polytechnic University, Tomsk, Russia. 149 p. (In Russian)
7 Flynn G (1967) Physics acoustic cavitation in liquids. Physical acoustics, ed. by Mezon U. World [Mir], Moscow, Russia. Part 1, Ch.B. P.7-138. (In Russian).
8 Khmelev VI, Khmelev SS, Naked RN, Barsukov RV (2010) Polzunovsky Bulletin [Polzunovsky vestnik] 3:321-325. (In Russian)
9 Lisichkin GV, AY Fadeev, Serdan AA et al. (2003) Chemistry grafted surface compounds [Khimiya privitykh poverkhnostnykh soyedineniy]. Fizmatlit, Moscow, Russia. 589 p. (In Russian). ISBN 5-9221-0342-3
10 (1986) Laboratory work and tasks of colloid chemistry, ed. by Frolov YuG, Grodskiy AS. Chemistry, Moscow, Russia. 214 p. (In Russian)
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