The method of production and modification of highly disperse silica for pharmaceutical and cosmetic preparations

  • Nina Nikolaevna Mofa Institue of Combustion Problems, Almaty
  • Assem Mukhtarkhanovna Kalieva Institue of Combustion Problems, Almaty
  • Tatyana Victorovna Chernoglazova Institue of Combustion Problems, Almaty
  • Tatyana Alexeevna Shabanova Institue of Combustion Problems, Almaty
  • Zhandarbek Zhanabiluly Sabayev Institue of Combustion Problems, Almaty
  • Bakhtiyar Seisembekovich Sadykov Institue of Combustion Problems, Almaty
  • Timur Bolatkhanovich Oserov Institue of Combustion Problems, Almaty
  • Konstantin Andreevich Vasin Institue of Combustion Problems, Almaty
  • Zulkhair Aimukhametovich Mansurov Institue of Combustion Problems, Almaty
Keywords: silicon dioxide, modification, ultrasonic treatment, mechanochemical treatment, encapsulation

Abstract

The change in the dispersity, morphology and state of amorphous silicon dioxide (silica) powder depending on the conditions of mechanochemical treatment (MCT) in the mill of dynamic action and ultrasonic treatment (UST) in different aqueous solution is considered. Production of silicon dioxide in a highly disperse state is of importance, when using it in cosmetic and pharmaceutical preparations. Nanosilicic compositions are effective for delivering medicines to the connective tissues of the skin structure. When dispersing powder as surfactant and modifying additives, we used monoatomic and triatomic alcohols as well as succinic and acetylsalicylic acids, which provide a high level of grinding, modification of the particle surface and stabilization of a highly active state of silicon dioxide. Electron-microscopic investigations on the morphology of particles showed their capsulation into dense modifying films under the conditions of MCT and UST. The use of acid modifiers in the process of MCT and UST of silicon dioxide powder resulted in formation of complex composition systems consisting of an inorganic nucleus and organic capsulating film. The state of the obtained modified powders was evaluated by the change of electrical resistance as one of the most sensitive indices of structural changes of the system being treated. The use of triatomic alcohol glycerine, when treating the powder, noticeably decreased its specific electrical resistance after UST, due to formation of hydroxylic groups on the surface of particles and accumulation of charged particles, which provide a high chemical activity of the systems. An important role of the capsulating polymer component on the surface of highly disperse particles of silicon dioxide for stabilization of a highly active state of the powder is shown.

Author Biography

Tatyana Victorovna Chernoglazova, Institue of Combustion Problems, Almaty

 

 

References

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Published
2015-12-30
How to Cite
Mofa, N., Kalieva, A., Chernoglazova, T., Shabanova, T., Sabayev, Z., Sadykov, B., Oserov, T., Vasin, K., & Mansurov, Z. (2015). The method of production and modification of highly disperse silica for pharmaceutical and cosmetic preparations. Chemical Bulletin of Kazakh National University, (4), 20-28. https://doi.org/https://doi.org/10.15328/cb652
Section
Colloid and Nano Chemistry