NMR spectroscopic studies of the supramolecular inclusion complexes of 1-(2-etoxyethyl)-4-(hexyne-1-yl)-4-benzoiloxypiperidine with β-cyclodextrin
In order to establish the formation of supramolecular inclusion complexes of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine with β-cyclodextrin and their structures, 1H and 13C NMR spectra of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine and its complexes with β-cyclodextrin were studied. The changes in the values of chemical shifts of 1H and 13C of substrate and receptor in their inclusion complexes with β-cyclodextrin have been determined. It has been established that inclusion complexes formed in the reaction of 1-(2-ethoxyethyl)-4-(hexyne-1-yl)-4-benzoyloxypiperidine with β-cyclodextrin. It was shown that the N-ethoxyethyl’s end of molecule substrates entered in the inner cavity of the receptor.
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