Determination of chemical composition of the Ligularia narynensis root by gas chromatography-mass spectrometry

  • Aliya K. Nurlybekova Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0001-9797-284X
  • Yang Ye Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China http://orcid.org/0000-0003-1316-5915
  • Zharylkasyn A. Abilov Faculty of Chemistry and Chemical Technology, al-Farabi Kazakh National University, Almaty, Kazakhstan https://orcid.org/0000-0002-2665-2539
  • Janar Jenis Faculty of Chemistry and Chemical Technology, al-Farabi Kazakh National University, Almaty, Kazakhstan; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; Research Center for Medicinal Plants, al-Farabi Kazakh National University, Almaty, Kazakhstan http://orcid.org/0000-0002-7148-7253
Keywords: Ligularia narynensis, hexane extract, liposoluble constituents, GC-MS

Abstract

Ligularia is a medicinally important herb of the family Compositae. Ligularia narynensis is a perennial herb growing in the mountains, rich in sesquiterpenes, triterpenes, lignans, alkaloids, and steroids. In this work chemical constituents of the root part of medicinal plant L. narynensis from Kazakhstan have been determined for the first time. The constituents of the root part of L. narynensis were extracted with hexane and analyzed by gas chromatography – mass spectrometry (GC-MS). Thirty compounds were detected, and their concentrations were determined by the method of normalization of peak areas. Among them, the major components are (9Z,12E)-octadeca-9,12-dienoic acid (16.7%), ethyl (9Z,12Z)-octadeca-9,12-dienoate (11.1%), n-hexadecanoic acid (11.0%), (3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-yl) acetate (9.1%), [(3R)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] acetate (5.1%). Presence of these bioactive constituents may indicate that the plant extract possesses anti-inflammatory, antimicrobial and anticancer activities, which can serve as a basis for the development of new phytopreparations.

References

1 Baitenov MS (2001) Flora of Kazakhstan [Flora Kazahstana]. Science, Almaty [Gylym, Almaty]. (In Russian). ISBN 9965-07-036-9

2 Gao X, Lin CJ, Xie WD, Shen T, Jia ZJ (2006) Helv Chim Acta 89:1387-1394. Crossref

3 Wang Q, Chen TH, Bastow KF, Morris-Natschke SL, Lee KH, Chen DF (2013) J Nat Prod 76:305-310. Crossref

4 Saito Y, Taniguchi M, Komiyama T, Ohsaki A, Okamoto Y, Gong X, et al. (2013) Tetrahedron 69:8505-8510. Crossref

5 Wu YX, Chen YJ, Liu CM, Gao K (2012) J Asian Nat Prod Res 14:1130-1136. Crossref

6 Xu X, Konirhan B, Zakaria B, Jenis J (2009) The Kazakh Herbal Medicine. Ethnic publishing house, Beijing. ISBN

7 Gao X, Jia ZJ (2008) Chinese Chem Lett 19:71-72. Crossref

8 Yang J-L, Wang R, Shi Y-P (2011) Nat Products Bioprospect 1:1-24. Crossref

9 Wang YM, Zhao JQ, Yang JL, Tao YD, Mei LJ, Shi YP (2017) Biochem Syst Ecol 72:8-11. Crossref

10 Wu L, Liao Z, Liu C, Jia H, Sun J (2016) Chem Biodivers 13:645-671. Crossref

11 Gao X, Xie WD, Jia ZJ (2008) J Asian Nat Prod Res 10:185-192. Crossref

12 Gao X, Shen T, Xie WD (2006) Chinese Chem Lett 17:341-343.

13 Nurlybekova A, Ye Y, Abilov ZhA, Dyusebaeva MA, Jenis J (2018) News of the National Academy of Sciences of the Republic of Kazakhstan. Series Chemistry and Technology 4:22-29.

14 Nurlybekova A, Ye Y, Jenis J (2018) International Journal of Biology and Chemistry 11:189-197. Crossref

15 Tang YL, Deng YR (2003) China J Chinese Mater Medica 28:627-629.

16 Cho HM, Yun MS, Yeon BR, Jhoo JW, Jung JU, Park YH (2012) J Agric Environ Sci 24:58-63. Crossref

17 Mirjalili MH, Y fzadi M (2012) Acta Biol Szeged 56:151-154.

18 Rahman MM, Ahmad SH, Mohamed MTM, Ab Rahman MZ (2014) Sci World J 2014:8. Crossref

19 Sudha T, Chidambarampillai S, Mohan VR (2013) J Appl Pharm Sci 3:126-130. Crossref

20 Aparna V, Dileep K V, Mandal PK, Karthe P, Sadasivan C, Haridas M (2012) Chem Biol Drug Des 80:434-439. Crossref

21 Harada H, Yamashita U, Kurihara H, Fukushi E, Kawabata J, Kamei Y (2002) Anticancer
Res 22:2587-2590.

22 Ravi L, Krishnan K (2016) Asian J Cell Biol 12:20-27. Crossref
Published
2019-12-05
How to Cite
Nurlybekova, A., Ye, Y., Abilov, Z., & Jenis, J. (2019). Determination of chemical composition of the Ligularia narynensis root by gas chromatography-mass spectrometry. Chemical Bulletin of Kazakh National University, (4), 14-19. https://doi.org/https://doi.org/10.15328/cb1096
Section
Other Papers