Calcium alginate microparticles containing anti-TB drugs
Abstract
This work presents the results of immobilization of anti-TB drugs rifampicin and fluconazole in alginate hydrogels. Release kinetics of rifampicin and fluconazole from swollen and dried calcium alginate microparticles were studied. It was revealed that the release of the drug from the swollen microparticles is higher than from the dried ones. The release of rifampicin from alginate microparticles coated with chitosan layer was studied. Slower drug release was observed for the thicker the layer of chitosan. At the chitosan coating thickness of 25 microns, 95-100% rifampicin release from the microparticles during 600-720 min was observed. When using coated alginate particles with a thickness of 65 and 125 microns, during this time interval, 60-70% of drug was released, respectively.
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