Calcium alginate microparticles containing anti-TB drugs

DOI: https://doi.org/10.15328/cb562
Keywords: calcium alginate, rifampicin, fluconazole, microparticle immobilization

Abstract

This work presents the results of immobilization of anti-TB drugs rifampicin and fluconazole in alginate hydrogels. Release kinetics of rifampicin and fluconazole from swollen and dried calcium alginate microparticles were studied. It was revealed that the release of the drug from the swollen microparticles is higher than from the dried ones. The release of rifampicin from alginate microparticles coated with chitosan layer was studied. Slower drug release was observed for the thicker the layer of chitosan. At the chitosan coating thickness of 25 microns, 95-100% rifampicin release from the microparticles during 600-720 min was observed. When using coated alginate particles with a thickness of 65 and 125 microns, during this time interval, 60-70% of drug was released, respectively.

References

1   Li L, Wang L, Shao Y, Ni R, Zhang T, Mao S (2013) Int J Pharm 450:197-207. http://dx.doi.org/10.1016/j.ijpharm.2013.04.052

2   Murtaza G, Waseem A, Hussain I (2011) Afr J Pharm Pharmaco 5:2726-2737. http://dx.doi.org/10.5897/AJPP11.706

3   Inagamov SY, Muhamedzhanova MY, Muhamedov GI (2011) Chemistry of Plant Raw Materials [Khimija Rastitel’nogo Syr’ja] 2:51-56. (In Russian)

4   Fernández Farrés I, Douaire M, Norton IT (2013) Food Hydrocolloid 32:115-122. http://dx.doi.org/10.1016/j.foodhyd.2012.12.009

5   Yang Y, Campanella OH, Hamaker BR, Zhang G, Gu Z (2013) Food Hydrocolloid 30:26-32. http://dx.doi.org/10.1016/j.foodhyd.2012.04.006

6   Arbex MA, Varella MCL, Siqueira HR, Mello FAF (2010) J Bras Pneumol 36:641-656. http://dx.doi.org/10.1590/s1806-37132010000500017

7   Shomuratov SA, Murodov EA, Turaev AS (2006) Chemistry of Plant Raw Materials [Khimija Rastitel’nogo Syr’ja] 2:25-28. (In Russian)

8   Ahmed MM, El-Rasoul SA, Auda SH, Ibrahim M (2013) Saudi Pharmaceuticals Journal 21:61-9. http://dx.doi.org/10.1016/j.jsps.2011.08.004

9   Mishin VY (2000) Attending Doctor [Lechashhij Vrach] 3:4-9. (In Russian)

10     Pankrusheva TA, Avtina TV, Pokrovskiy MV, Medvedeva OA (2010) Scientific Bulletin of BelSU. Medicine. Pharmacy Series [Nauchnyie Vedomosti Belgu. Seriya: Meditsina. Farmatsiya] 12-2:40-46. (In Russian)

11     Consiglieri VO, Mourao S, Sampaio M, Granizo P, Garcia P, Martinello V, Spricigo R, Gomes Ferras H (2010) Brazilian J Pharm Sci 46:115–120. http://dx.doi.org/10.1590/S1984-82502010000100013

12     Simonoska CM, Glavas DM, Goracinova K (2008) Eur J Pharm Biopharm 68:565-578. http://dx.doi.org/10.1016/j.ejpb.2007.06.007

13     Mohammadi-Samani S, Miri R, Salmanpour M, Khalighian R, Sotoudeh S, Erfani N (2013) Res Pharm Sci 8:25-33.

Published
2015-06-30
How to Cite
Bakhytkyzy, I., & Musabekov, K. (2015). Calcium alginate microparticles containing anti-TB drugs. Chemical Bulletin of Kazakh National University, 78(2), 14-20. https://doi.org/https://doi.org/10.15328/cb562
Issue
Vol 78 No 2 (2015): Chemical Bulletin of Kazakh National University
Section
Colloid and Nano Chemistry
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-NC-ND 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.