Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives

  • Moldir Dyusebaeva al-Farabi Kazakh National University
  • Zhanar Zhenis al-Farabi Kazakh National University
  • Sholpan Akhmedova al-Farabi Kazakh National University
Keywords: piperidine, morpholine, acetylenes alcohols, Mannich reaction, biologically activity

Abstract

A synthesis of potentially biologically active heterocyclic amino alcohols of acetylene (Piperidine and Morpholine) under the conditions of Mannich reaction accomplished and received their acyl derivatives. Pharmacological activity (antibacterial and antispasmotic) of synthesized compounds, also acute toxicological characteristics studied. The study showed that the combination of DMAE-4 has antispasmodic activity with low toxicity. 

References

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Published
2015-03-31
How to Cite
Dyusebaeva, M., Zhenis, Z., & Akhmedova, S. (2015). Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives. Chemical Bulletin of Kazakh National University, (1), 36-43. https://doi.org/https://doi.org/10.15328/cb490
Section
Organic and Polymers Chemistry