TY - JOUR AU - Moldir Dyusebaeva AU - Zhanar Zhenis AU - Sholpan Akhmedova PY - 2015/03/31 Y2 - 2024/03/29 TI - Synthesis of acetylene alcohols of heterocyclic type and the acyl derivatives JF - Chemical Bulletin of Kazakh National University JA - KazNUCB VL - 77 IS - 1 SE - Organic and Polymers Chemistry DO - https://doi.org/10.15328/cb490 UR - https://bulletin.chemistry.kz/index.php/kaznu/article/view/490 AB - A synthesis of potentially biologically active heterocyclic amino alcohols of acetylene (Piperidine and Morpholine) under the conditions of Mannich reaction accomplished and received their acyl derivatives. Pharmacological activity (antibacterial and antispasmotic) of synthesized compounds, also acute toxicological characteristics studied. The study showed that the combination of DMAE-4 has antispasmodic activity with low toxicity.  ER -