Study of the kinetics of the release of lipophilic ingredients from capsules using synthetic and natural systems

Abstract

In the work, the kinetics of the release of vitamin E and polyphyte oil from capsules was studied using synthetic and natural systems. The release of active ingredients was monitored on a Cary 50 Cons UV spectrophotometer equipped with CaryWinUV software. The kinetics of the release of vitamin E from capsules stabilized with sodium caseinate and then coated with chitosan shows a sustained prolonged release of 20% of vitamin E within 1 h, within 5 h about 45% is released, within 48 h about 80%. It was found that the efficiency of capsulation of vitamin E is higher than that of polyphyte oil, the release of vitamin E is more delayed and prolonged in comparison with polyphyte oil. The release of vitamin E from capsules stabilized with a synthetic system polymer-surfactant / vitamin E) chitosan) polystyrene sulfonate PSS was also investigated. It was determined that the release of vitamin E from capsules stabilized by a synthetic system (polymer-surfactant and coated with two layers of oppositely charged polyelectrolyte by the Layer-by-Layer method) is prolonged, within 1 h – 23% of vitamin E is released, 70% – within 12 h and 100% – within 80 h.